There are many different types of dermal fillers and many manufacturers. Skinpossible only uses filler that is made from Hyaluronic Acid which is a naturally-occurring substance in our skin (Juvederm™, Restylane™, Teosyal™). The products we use are all derived from plants, not animal products. Other fillers classified as semi-permanent or permanent can be made from Collagen (Zyplast™/Zyderm™) or from synthetic products such as calcium hydroxyapapite (Radiesse™). Fillers can even be made, fully or in part, from acrylics or plastics or even silicone. Skinpossible will not use synthetic fillers and will not do fillers for you if you have had certain products previously injected (Bioaclamide™, Dermalive™, Dermadeep™,Beauticall™,Artecol™, Artesense™). As a matter of interest regarding synthetic permanent fillers, that is what happened to Priscilla Presley.