It is true that Latisse use has been associated with iris pigmentation and this is the result of using more medication that is required.  It is extremely important to strictly observe the following measures.  Do not apply directly to the eye.  Do not add more than one drop to an applicator.  Blot any excess solution outside the upper eyelid margin with a tissue or other absorbent mate-rial.  Do not administer the medication more than once daily.  Do not reuse applicators.